Danny Ings scored the winner in the first at St Mary’s, as the hosts claimed all three points.
The defeat was compounded by injuries to Harry Kane, who strained his hamstring and Ndombele, who was taken off with what appeared to be a groin injury.
The Frenchman’s latest setback attracted harsh remarks from Mourinho.
“He’s always injured. He’s injured, he’s not injured, he plays one match.
“This is the same since the beginning of the season,” the Portuguese told reporters after the game
Affairsofnaija Reports (AON)