Xavi’s side were rewarded for knocking out contenders Napoli with a fairer tie with Galatasaray with the first leg to be played at Camp Nou on Thursday, March 10.
In other ties in the Round-of-16, West Ham United will play against Sevilla while Atalanta will host Bayer Leverkusen in the first leg of their tie.
Zaidu Sanusi’s Porto will face Lyon for a quarterfinal spot while the trio of Joe Aribo, Calvin Bassey, and Leon Balogun will help Rangers find a way past Serbian side Red Star Belgrade.
Full Europa League Round-of-16 draw
Rangers vs Red Star Belgrade
Atalanta vs Bayer Leverkusen
RB Leipzig vs Spartak Moscow
Real Betis vs Eintracht Frankfurt
The two-legged ties will be played on Thursday 10 March and Thursday 17 March.